As we have seen before, sometimes actors' egos sometimes affect the relationships between film co-stars, resulting in hurt feelings, violence and general on-set animosity.
But when the co-star you're falling out is supposed to be the person that you're deliriously in love with, then it becomes a bigger challenge.
So here are a dozen of onscreen couples who just couldn't get along...
12. Shannen Doherty adds Mallrats co-star Jason Lee to her list of enemies
For Mallrats, the follow-up to his cult classic Clerks, director Kevin Smith teamed up Beverly Hills 90210 star Shannen Doherty with Jason Lee, in his first major role.
Doherty - who seems to have a knack for rubbing people up the wrong way - didn't get on well with Lee, who found his co-star remarkably unpleasant to work with.
Lee joined the club, which included Doherty's onscreen brother on Beverly Hills 90210, Jason Priestly and went on to anger her Charmed co-star Alyssa Milano, both labelling the actress 'difficult to work with'.
All of this might explain why Doherty never hit it big in the acting game, relegated to TV movies and small screen series.
11. Leonardo DiCaprio played pranks on 'uptight' Claire Danes on Romeo + Juliet
The pair, who played the most fictional famous lovers in history didn't get on as well as their Shakespearian counterparts.
Danes reportedly felt a pre-Titanic DiCaprio to be "very immature" and he often played pranks on her and the rest of the crew during production.
DiCaprio, meanwhile, felt the actress to be very uptight and the pair would often ignore each other between takes.
Despite this, Danes later revealed that the young stars possibly could have had a real-life romance, as they had "a spark, but I don’t think either of us knew how to handle it.
"So, we sometimes sort of ignored each other. It was too big for us to really accept."
10. Julia Roberts calls Nick Nolte disgusting, the feeling is mutual
Another onscreen romance that showed less than love when the cameras stopped rolling, Julia Roberts and Nick Nolte starred on the forgettable 1994 rom-com I Love Trouble, which Nolte declared that it's the worst film he's ever appeared in and claimed he only did it for the money.
The pair's contempt for each other resulted in them having to shoot the scenes separately - which isn't great when they're supposed to be the film's star couple.
Long after the film was completed, Roberts labelled Nolte "completely disgusting" and the worst actor she's ever worked with, while Nolte responded by saying she was "not a nice person, everyone knows that."
9. Pierce Brosnan shouted at Teri Hatcher for having morning sickness
Bond's 1997 outing for Tomorrow Never Dies provided us with a (thinly-veiled Rupert Murdoch-likey) media mogul villain Elliot Carver and his wife Paris Carver, played by Lois & Clark: The New Adventures of Superman and future Desperate Housewives star Terri Hatcher.
Hatcher's constant lateness annoyed Pierce Brosnan, who was filling out the 007 tuxedo at the time, and she annoyed him with her lax timekeeping.
Brosnan explained to Italian Vanity Fair: "I got very upset with her - she was always keeping me waiting for hours. I must admit I let slip a few words which weren't very nice."
Brosnan later found out that Hatcher had been suffering from morning sickness, but Brosnan wasn't all that bothered about throwing some expletives her way.
Brosnan candidly revealed: "It came out one morning that Teri was pregnant and she hadn't been feeling very well. Still, these things happen."
It wasn't all one way though, as it was rumoured that Hatched deliberately slapped Brosnan hard during a stunt sequence.
8. Sharon Stone bit Billy Baldwin's tongue so hard he couldn't speak
Sharon Stone is well known in Hollywood for making enemies on the sets of her films, and she did so with the second (or third) most-famous Baldwin.
Stone starred with Billy Baldwin in the Razzie Award-nominated 'erotic thriller' Sliver off the back of her Basic Instinct success, and the onscreen couple's passion was more leaning towards hatred than romance.
To amuse herself between takes, Stone would 'torture' Baldwin, including during one kissing scene, when she allegedly bit her co-star's tongue so hard that he wasn't able to speak properly for a week.
Prior to this, in one of her early films, Stone annoyed the crew so much that they urinated in a bathtub in which she was due to film a scene.
7. Patrick Swayze found Jennifer Grey emotionally unstable during Dirty Dancing
Patrick Swayze had to convince Jennifer Grey to star in the much-loved chick flick because she had such a low opinion of him from them working together on 1984's Red Dawn.
But Swayze came to regret that decision as her grew to hate working with her.
In his autobiography, which was released shortly after the star's death, Swayze revealed that Grey was too sensitive on set.
"We did have a few moments of friction when we were tired or after a long day of shooting.
"She seemed particularly emotional, sometimes bursting into tears if someone criticised her," he wrote about Grey's behaviour.
"Other times, she slipped into silly moods, forcing us to do scenes over and over again when she'd start laughing."
Swayze forgave her for her on-set antics as the pair eventually became friends and Swayze revealed that Grey did a "truly phenomenal job" and that "in many ways, she made the movie."
6. Reese Witherspoon and Vince Vaughn are unsurprisingly extremely different actors
The pair were cast in the 2008 festive rom-com Four Christmases as a married couple who must visit all four of their divorced parents on Christmas Day, probably with mildly-hilarious consequences.
According to insiders on the set, the two clashed due to their vastly differing personalities, one-take wonder Reese wanted to diligently plan out each scene to perfection, while notorious ad-libber Vaughn wanted to play around with and see where the scene would go.
When the film was released and the two were set to engulf on a substantial promo tour, Reese tried to laugh off the reports, stating that the two got along just fine, and a good time was had by all.
Her glowing endorsement of her co-star wasn't all too believable, as everyone knew their true feelings towards each other.
5. Debra Winger upsets Richard Gere and half of Hollywood
During the height of her career, Debra Winger was a notoriously 'challenging' actress, including walking off the set of A League of Their Own and being labelled as 'nothing more than a catwalk model' by John Malkovich.
It was on the set of An Officer and a Gentleman, where Richard Gere (who had co-star issues of his own) and Winger would reportedly argue non-stop on the set.
Winger dubbed Gere a "brick wall" and the director Taylor Hackford "an animal" and despises the movie and tries to deny any involvement of her performance.
These days she and Gere are on more civil terms, as she explained to The Guardian: "I run in to Richard Gere quite a lot and he half jokes: 'Are you still saying terrible things about me?'"
4. Anthony Hopkins labels Downton's Shirley MacLaine 'obnoxious'
While filming the 1980 disappointing drama A Change of Seasons about a philandering married couple, the pair playing the married couple - Anthony Hopkins and Shirley MacLaine - got on even worse than the cheating onscreen couple.
MacLaine - who went on to play Cora Crawley's mother Martha Levinson on Downton Abbey - was another Hollywood star who wasn't in the habit of endearing herself to her colleagues.
While filming A Change of Seasons, Hannibal Lector proclaimed that MacLaine was "the most obnoxious actress I have ever worked with".
Despite the acting powerhouse that he is, Hopkins wasn't able to mask his disdain for his co-star in his performance, and was nominated for the Worst Actor award in the first ever Razzie Awards.
Unfortunately there are no further details about what caused the pair's falling out, but it is likely it was Shirley MacLaine being Shirley MacLaine, as director Don Seigel explained: "It's hard to feel much warmth for her."
3. Tony Curtis compares Marilyn Monroe to Hitler
One of the most iconic scenes in film is Marilyn Monroe standing on a drain or a grate or something while holding down her skirt which is billowing up from the draft, but these days, many don't even know what film it is from.
It is actually in 1969 comedy Some Like It Hot also starring Tony Curtis and Jack Lemmon, and was voted one of the finest comedy films by the American Film Institute.
Curtis and Lemmon play jazz musicians who are forced to dress in drag to disguise themselves as they flee from the mafia after witnessing the infamous 1929 Chicago mob-killing, The Saint Valentine's Day Massacre.
Tony Curtis' love interest was the skirt-billowing Marilyn Monroe, who was regarded as the most desirable women in the world, but declared kissing Monroe was "like kissing Hitler."
Many believe Curtis was angry with Marilyn because of her irresponsible and self-centred behaviour on set, and needing numerous retakes, including requiring 47 takes to say "It's me, Sugar" and another 40 takes to ask "Where's the bourbon?"
Curtis claimed that he made the 'Hitler' comment because he was fed up with people asking what it was like to smooch the legendary beauty: "It's like kissing Hitler. What are you doing asking me such a stupid question?"
Although he may have been trying to smooth the waters as when discussing a scene in which the pair were getting cosy aboard a yacht, Curtis remarked: "It was awful. She nearly choked me to death by deliberately sticking her tongue down my throat into my windpipe."
So maybe Hitler had terrible tongue technique with his kisses like Marilyn.
2. Jamie Dornan and Dakota Johnson have no chemistry whatsoever
One of 2015 most-anticipated films was the adaptation of E.L. James' 'mummy porn' erotic novel Fifty Shades of Grey.
The film was littered with issues from the get-go, director Sam Taylor-Johnson clashed with E.L. James over the film's direction, and how much control the book's author was allowed.
Another problem was leading co-stars Jamie Dornan and Dakota Johnson, who many fans and critics claimed had zero on screen chemistry, despite playing a madly-in-love couple.
Johnson described filming Fifty Shades' many sex scenes as a task, while Dornan stated that he found the raunchy filming so unpleasant that he would "take a long shower" before returning home to his wife.
Then, on the Fifty Shades publicity tour, the actors were unable to hide their unhappiness and contempt for each other with their awkward body language and coldness.
Still though, the actors are contracted in for the two Fifty Shades sequels, so look forward to more passionless scenes between the pair.
Check out this interview with the couple, where they couldn't look more awkard, even if they tried:
1. Ryan Gosling tried to get Rachel McAdams kicked off The Notebook
Probably the most-adored romantic drama of the noughties, the Nicholas Sparks novel featuring the romance between a country boy and a rich heiress despite disapproving parents and husbands getting in the way.
It will come as a shock to many teenage girls that the actors playing Noah and Allie didn't get along when the cameras weren't rolling.
After another lukewarm take, Ryan Gosling called director Nick Cassavetes over and requested: "Would you take her out of here and bring in another actress to read off camera with me?
"I can't. I can't do it with her. I'm just not getting anything from this."
Cassacetes got Gosling and co-star Rachel McAdams into a room and let the two shout and scream at each other, and the pair cracked on with it.
"The rest of the film wasn't smooth sailing, but it was smoother sailing" explained Cassavetes.
The impromptu therapy session had worked better than the director had realised, as once filming had wrapped, Ryan Gosling and Rachel McAdams started dating and were together for four years.